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To determine the selectivity profile of the inhibitors in MV4-11 and U937 cells, a chemical proteomics experiment using XO44 as a cell-permeable

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slotxo44 XO44 efficiently labels purified recombinant CDK4-CycD1 dimer but not trimer complexes with p21 or p27 as determined by electrospray ionization mass

xo44 Taunton et al reported a chemoproteomic Ar-SO2F-containing probe XO44 to target the catalytic lysine in >100 kinases Other Ar-SO2F